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In case of phenylketonuria (a hereditary metabolic disease) it must be observed that this drug contains an amount of the sweetener Aspartame corresponding to 11.22 mg phenylalanine.
Effervescent tablets contain sodium; consider acetylcysteine treatment as a source of sodium in patients who may be sensitive to excess sodium intake.
Serious skin reactions such as Stevens-Johnson syndrome and Lyell's syndrome have very rarely been reported in temporal connection with the use of acetylcysteine. In most cases, at least one other suspect medicinal product, which was more likely the cause of the mucocutaneous syndrome could be identified. If cutaneous or mucosal alterations newly occur, immediate medical advice should be sought and the treatment with acetylcysteine should be discontinued immediately.
